Glomerular Deposition of Hepatitis C Virus in Membranoproliferative Glomerulonephritis

Rituximab therapy for hepatitis C virus‐associated cryoglobulinemic membranoproliferative glomerulonephritis

Membranoproliferative glomerulonephritis associated with mixed cryoglobulinemia is the most common form of kidney disease observed in relation to hepatitis C virus (HCV) infection. Rituximab, a monoclonal antibody against CD20, is an effective treatment for severe and/or refractory HCV-related vasculitis and may evade the need for dialysis as in our patient.

Delayed spontaneous resolution of nephrotic syndrome in a patient with hepatitis C virus-associated membranoproliferative glomerulonephritis

Treatment with antiviral and/or immunosuppressive therapy is considered the standard care in patients with hepatitis C virus (HCV)-associated membranoproliferative glomerulonephritis (MPGN). However, even with an adequate therapy, a favourable response is not always guaranteed. In patients with HCV-associated MPGN, a delayed spontaneous remission of nephrotic syndrome is rare. We present here o...

Rituximab induces regression of hepatitis C virus-related membranoproliferative glomerulonephritis in a renal allograft.

Hepatitis C virus (HCV) infection complicates clinical outcome in liver and renal allografts [1]. Besides its important contribution to chronic liver disease, HCV infection is also a relevant cause of de novo immunemediated glomerulonephritis in both kidney and liver transplantation [2,3]. It has been shown that the development of de novo membranous and especially membranoproliferative glomerul...

Hepatitis C Virus Associated Glomerulonephritis

A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition

BACKGROUND It is sometimes challenging to diagnose unsusual cases of fibrillary glomerulonephritis (FGN) and immunotactoid glomerulopathy (ITG), the rare causes of nephrotic syndrome. CASE PRESENTATION A 75-year-old Japanese woman presented with nephrotic syndrome, microhematuria and renal insufficiency. Renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) with IgM and weak C...